CD41/CD61 antibodies, human

CD41/CD61 antibodies, human

Clone: REA607 | Dilution: 1:50
Clone REA607 recognizes the CD41/CD61 complex, also known as gpIIb/IIIa complex or integrin αIIbβ3. This cell adhesion molecule is a α/β transmembrane heterodimer of the ubiquitous integrin superfamily which is expressed by megakaryocytes and platelets. The CD41/CD61 complex plays an significant role in hemostasis and is also involved in fibrinogen binding and platelet aggregation.
Additional Information: Clone REA607 displays negligible binding to Fc receptors.

Alternative Names

gpIIb/IIIa complex, integrin αIIbβ3

Technical specifications

  • Antigen: CD41/CD61
  • Clone: REA607
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: gpIIb/IIIa complex, integrin αIIbβ3
  • Entrez Gene ID: 3674, 3690
  • Distribution of antigen: megakaryocytes, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC-Vio770
  • Selected References

    1. Naik, U. P. et al. (1997) Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J. Biol. Chem. 272(8): 4651-4654
    2. Podolnikova, N. P. et al. (2014) The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain. J. Biol. Chem. 289(4): 2371-2383
    3. Corbel, C. et al. (2005) (alpha)IIb Integrin, a novel marker for hemopoietic progenitor cells. Int. J. Dev. Biol. 49(2-3): 279-284