CD41 antibodies, mouse

CD41 antibodies, mouse

Clone: MWReg30 | Dilution: 1:50
Clone MWReg30 recognizes the mouse CD41 antigen, a single-pass type I membrane protein also known as integrin α2b or GPIIb. CD41 associates with CD61 to form the heterodimeric gpIIb/gpIIIa complex that is present on megakaryocytes, platelets, and early hematopoietic progenitors. The CD41/CD61 complex is a receptor for several adhesion molecules such as fibronectin, fibrinogen, plasminogen, and vitronectin and mediates platelets aggregation. CD41 expression marks the divergence of definitive hematopoietic precursors from the hemangioblasts or hemogenic endothelium during mouse embryonic development.

Alternative names

ITGA2B, GPIIb, CD41b, alphaIIb, GPalpha IIb

Technical specifications

  • Antigen: CD41
  • Clone: MWReg30
  • Isotype: rat IgG1κ
  • Isotype control: Rat IgG1 – isotype control antibodies
  • Alternative names of antigen: ITGA2B, GPIIb, CD41b, alphaIIb, GPalpha IIb
  • Entrez Gene ID: 16399
  • Molecular mass of antigen [kDa]: 109
  • Distribution of antigen: megakaryocytes, platelets, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Mikkola, H. K. et al. (2003) Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood 101(2): 508-516
    2. Thornton, M. A. et al. (1999) Characterization of the murine platelet alphaIIb gene and encoded cDNA. Blood 94(11): 3947-3950
    3. Chen, Y. Q. et al. (1992) Identification of the alpha IIb beta 3 integrin in murine tumor cells. J. Biol. Chem. 267(24): 17314-17320
Product options: 1

CD41-APC, mouse

30 µg in 200 µL (1)