CD40 antibodies – functional grade, mouse

CD40 antibodies – functional grade, mouse

Clone: FGK45.5
Clone FGK45.5 recognizes the mouse CD40 antigen, a 40–50 kDa glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily. CD40 is expressed on B lymphocytes, macrophages, and dendritic cells and is an important costimulatory molecule for B cells as well as dendritic cells, monocytes, and other antigen-presenting cells (APCs). The interaction of CD40 on B cells with its ligand CD154 is involved in B cell activation and differentiation; engagement of CD40 on dendritic cells leads to maturation. Clone FGK45 can be used for blocking of CD40/CD154 interaction and for
in vitro
and
in vivo
activation of CD40-expressing APCs.

Applications

The CD40 pure – functional grade antibody is suited for functional assays, for example,
in vitro
and
in vivo
activation and maturation of antigen presenting cells, and blocking of CD40-CD154 (CD40L) binding.

Alternative Names

Bp50, gp39, HIGM1, IGM, IMD3, T-BAM, TRAP, TNFRSF5, p50

Technical specifications

  • Antigen: CD40
  • Clone: FGK45.5
  • Isotype: rat IgG2a
  • Alternative names of antigen: Bp50, gp39, HIGM1, IGM, IMD3, T-BAM, TRAP, TNFRSF5, p50
  • Entrez Gene ID: 21939
  • Molecular mass of antigen [kDa]: 30
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, epithelial cells, fibroblasts, Langerhans cells, leukemia cells, lymphocytes, macrophages, mast cells, monocytes, plasma cells, platelets
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
Product options: 2

Product information

Size
Order no.
Price

CD40 pure - functional grade, mouse

  • FGK45.5
  • For research use only
100 µg in 1 mL
130-093-022
-

CD40 pure - functional grade, mouse

  • FGK45.5
  • For research use only
1 mg in 0.5 mL
130-093-023
-

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