CD40 antibodies – functional grade, human

CD40 antibodies – functional grade, human

Clone: HB14
The HB14 monoclonal antibody reacts with human CD40, a 45–50 kDa type I transmembrane glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed primarily on B cells, macrophages, follicular dendritic cells, endothelial cells, and fibroblasts and at lower levels on plasma cells and a subset of peripheral T cells. CD40 is involved in B cell differentiation and proliferation, isotype class-switching, and protection of B cells from apoptosis. Interaction of CD40 with its ligand CD154 is important in T cell–B cell interaction and plays a role in costimulation and immune regulation.
Clone HB14 blocks the binding of CD40 to CD154. This prevents down-regulation of CD154 expression induced by interaction with CD40 expressed on antigen-presenting cells.

Applications

This pure – functional grade antibody is suited for cell culture functional assays, for example, blocking of receptor-ligand binding.

Alternative Names

Bp50, CDW40, TNFRSF5, p50

Technical specifications

  • Antigen: CD40
  • Clone: HB14
  • Isotype: mouse IgG1
  • Alternative names of antigen: Bp50, CDW40, TNFRSF5, p50
  • Entrez Gene ID: 958
  • Molecular mass of antigen [kDa]: 28
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, epithelial cells, fibroblasts, Langerhans cells, leukemia cells, lymphocytes, macrophages, mast cells, monocytes, plasma cells, platelets
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
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