CD4 antibodies, mouse

CD4 antibodies, mouse

Clone: REA604 | Dilution: 1:50
Clone REA604 recognizes the mouse CD4 antigen, a cell surface glycoprotein, which is a member of the immunoglobulin superfamily. It is also known as L3T4 or Leu-3. In mice, CD4 is expressed on T helper cells, regulatory T cells, and at lower levels on subpopulations of NKT cells and dendritic cells. It is furthermore detected on most thymocytes (CD4
and CD4
thymocytes). CD4 interacts with MHC class II molecules on the surface of antigen-presenting cells. It increases the avidity of the interaction between T cells and antigen-presenting or target cells.
Additional information: Clone REA604 displays negligible binding to Fc receptors.

Alternative Names

L3T4, T4, Leu-3, Ly-4
REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the different hybridoma clones. 
Other clonesOverlap in epitope recognition with REA604

Technical specifications

  • Antigen: CD4
  • Clone: REA604
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: L3T4, T4, Leu-3, Ly-4
  • Entrez Gene ID: 12504
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: T cells, NKT cells, dendritic cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, APC-Vio770, PerCP-Vio700
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