CD4 antibodies, human

CD4 antibodies, human

Clone: REA623 | Dilution: 1:11
Clone REA623 recognizes the human CD4 antigen, a 55 kDa single-pass type I membrane protein, also known as T4/Leu-3. CD4 is highly expressed on T helper cells and at a lower level on monocytes and dendritic cells. It is involved in the recognition of MHC class II/peptide complexes by the TCR heterodimers and is the receptor for the human immunodeficiency virus (HIV).
Additional information: Clone REA623 displays negligible binding to Fc receptors.

Alternative Names

T4, Leu-3, CD4mut

Technical specifications

  • Antigen: CD4
  • Clone: REA623
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: T4, Leu-3, CD4mut
  • Entrez Gene ID: 920
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: monocytes, T cells, thymocytes, T helper cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, Biotin

Specificity

In order to compare the epitope specificity of REAfinity Clone REA623 with other known clones, a competition assay was performed.
 Cells were incubated with an excess of purified unconjugated REAfinity Antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.
 

Other clonesOverlap in epitope recognition with REA623
RPA-T4-
SK3++
OKT4-
Vit4.3-
M-T466++
M-T321++
Product options: 2
130-109-529

CD4-Biotin, human

for 30
tests
(1)
-
130-109-450

CD4-Biotin, human

for 100
tests
(1)
-

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