CD39 antibodies, human

Clone: MZ18-23C8 | Dilution: 1:50
The CD39 antibody specifically recognizes the membrane-bound human CD39 antigen, which is expressed on an effector/memory-like subset of FoxP3
+
regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. In concert with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells.
Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells.

Alternative Names

Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80

Cross-reactivity

This antibody is tested to cross-react with rhesus monkey (
Macaca mulatta
) cells.

Technical specifications

  • Antigen: CD39
  • Clone: MZ18-23C8
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80
  • Entrez Gene ID: 953
  • Molecular mass of antigen [kDa]: 58
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, Langerhans cells, lymphocytes, macrophages, monocytes, NK cells, placenta, platelets, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE

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