CD370 (CLEC9A) antibodies, mouse

CD370 (CLEC9A) antibodies, mouse

Clone: REA941 | Dilution: 1:50
Clone REA941 recognizes CD370 (CLEC9A) C-type lectin 9A, also known as DC NK lectin group receptor-1 (DNGR-1). It is a type II transmembrane glycoprotein of 264 amino acids expressed at high level on CD8a
+
dendritic cells and at lower level on mPDCA-1
+
plasmacytoid dendritic cells. CD370 (CLEC9A) recognizes necrotic cell associated epitopes and plays an important role in crosspresentation of dead cell derived antigens.
Additional information: Clone REA941 displays negligible binding to Fc receptors.

Alternative Names

DNGR-1, CLEC9A

Technical specifications

  • Antigen: CD370 (CLEC9A)
  • Clone: REA941
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: DNGR-1, CLEC9A
  • Entrez Gene ID: 232414
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: dendritic cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Biotin
  • Selected References

    1. Sancho, D. et al. (2008) Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J. Clin. Invest. 118(6): 2098-2110
    2. Sancho, D. et al. (2009) Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458(7240): 899-903
    3. Joffre, O. P. et al. (2010)
      Efficient and versatile manipulation of the peripheral CD4
      +
      T-cell compartment by antigen targeting to DNGR-1/CLEC9A.
      Eur. J. Immunol. 40(5): 1255-1265
Product options: 10
130-117-646

CD370 (CLEC9A)-FITC, mouse

30 µg in 200 µL (1)
-
130-117-496

CD370 (CLEC9A)-FITC, mouse

150 µg in 1 mL (1)
-
130-115-622

CD370 (CLEC9A)-PE, mouse

30 µg in 200 µL (1)
-
130-115-528

CD370 (CLEC9A)-PE, mouse

150 µg in 1 mL (1)
-
130-115-623

CD370 (CLEC9A)-APC, mouse

30 µg in 200 µL (1)
-
130-115-529

CD370 (CLEC9A)-APC, mouse

150 µg in 1 mL (1)
-
130-115-625

CD370 (CLEC9A)-PE-Vio615, mouse

30 µg in 200 µL (1)
-
130-115-531

CD370 (CLEC9A)-PE-Vio615, mouse

150 µg in 1 mL (1)
-
130-115-621

CD370 (CLEC9A)-Biotin, mouse

30 µg in 200 µL (1)
-
130-115-527

CD370 (CLEC9A)-Biotin, mouse

150 µg in 1 mL (1)
-