CD37 antibodies, human

CD37 antibodies, human

Clone: REA366 | Dilution: 1:11
Clone REA366 recognizes the human CD37 antigen, a multi-pass membrane protein which is also known as tetraspanin-26 (Tspan-26). CD37 is a member of the transmembrane 4 superfamily of tetraspanin proteins, which consist of 4 potential membrane-spanning regions, 2 extracellular loops, and 2 short intracytoplasmic tails. Although most tetraspanins are ubiquitous proteins, CD37 expression is nearly exclusively limited to mature B cells and B cell–derived lymphoid malignancies. B cell early progenitors, T cells, natural killer cells, and myeloid cells exhibit only minimal amounts of membrane-associated CD37. In innate immunity, CD37 interacts with pattern recognition receptor dectin-1, stabilizing dectin-1 at the macrophage cell surface, and negatively regulating proinflammatory cytokine secretion following ligand recognition. Adaptive humoral immune responses are also perturbed by CD37 ablation. In cellular immunity, CD37 negatively regulates T cell proliferation. In APCs, CD37 associates with MHC class II at the cell surface and has been shown to negatively regulate antigen presentation. CD37 has recently attracted interest as a target for monoclonal antibodies with therapeutic potential in B cell malignancies.
Additional information: Clone REA366 displays negligible binding to Fc receptors.

Alternative Names

GP52-40, TSPAN26

Technical specifications

  • Antigen: CD37
  • Clone: REA366
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: GP52-40, TSPAN26
  • Entrez Gene ID: 951
  • Molecular mass of antigen [kDa]: 32
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
Product options: 16

Product information

Size
Order no.
Price

CD37-FITC, human

  • REA366
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-285
-

CD37-FITC, human

  • REA366
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-243
-

CD37-PE, human

  • REA366
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-286
-

CD37-PE, human

  • REA366
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-244
-

CD37-APC, human

  • REA366
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-287
-

CD37-APC, human

  • REA366
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-245
-

CD37-VioBlue, human

  • REA366
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-284
-

CD37-VioBlue, human

  • REA366
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-242
-

CD37-PE-Vio770, human

  • REA366
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-385
-

CD37-PE-Vio770, human

  • REA366
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-344
-

CD37-APC-Vio770, human

  • REA366
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-288
-

CD37-APC-Vio770, human

  • REA366
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-246
-

CD37-PerCP-Vio700, human

  • REA366
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-289
-

CD37-PerCP-Vio700, human

  • REA366
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-247
-

CD37-Biotin, human

  • REA366
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-283
-

CD37-Biotin, human

  • REA366
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-241
-

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