CD360 (IL-21R) antibodies, human

CD360 (IL-21R) antibodies, human

Clone: REA233 | Dilution: 1:11
Clone REA233 recognizes CD360, which is also known as interleukin 21 (IL-21) receptor. CD360 forms a heterodimer with the common γ subunit, which is shared by other receptors such as IL-2 and IL-15 receptor and serves as the receptor for IL-21. CD360 is a single-pass type I membrane protein and belongs to the type I cytokine receptor family. Expression of CD360 is found on variety of cells including B cells, NK cells subsets, T cells, NKT cells, dendritic cells, macrophages, and non-hematopoietic cells such as keratinocytes and fibroblasts. CD360 is composed of the cytokine-binding domain, a transmembrane domain and a large intracellular domain that contains conserved structural motifs, including the commonly described box 1 and box 2 elements, which are important for signal transduction. IL-21 mediated signaling plays vital role in mediating immune response and is involved in enhancement of adaptive T cell–immunity, antibody production, activation of natural killer cell subtypes, and opposing the suppressive effects mediated by regulatory T cells.
Additional information: Clone REA233 displays negligible binding to Fc receptors.

Alternative Names


Technical specifications

  • Antigen: CD360 (IL-21R)
  • Clone: REA233
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL21R, NILR
  • Distribution of antigen: B cells, dendritic cells, T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
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