CD357 (GITR) antibodies, mouse

CD357 (GITR) antibodies, mouse

Clone: DTA-1 | Dilution: 1:10
Clone DTA-1 specifically recognizes mouse GITR (Glucocorticoid-induced TNF-receptor), a member of the TNF receptor superfamily also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD4
+
CD25
+
regulatory T cells (Tregs). Activation of T cells upregulates GITR expression. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. GITR plays an important role in the function of CD4
+
CD25
+
Tregs.

Alternative Names

TNFRSF18, AITR

Technical specifications

  • Antigen: GITR
  • Clone: DTA-1
  • Isotype: rat IgG2bκ
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: TNFRSF18, AITR
  • Entrez Gene ID: 21936
  • Molecular mass of antigen [kDa]: 23
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, pure
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