CD357 (GITR) antibodies, human

CD357 (GITR) antibodies, human

Clone: REA1007 | Dilution: 1:50
Clone REA1007 recognizes the human CD357 antigen, also known as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) or TNFRSF18, which is an inducible type I transmembrane protein and a member of the tumor necrosis factor receptor (TNFR) superfamily. CD357 is expressed at low levels on thymocyte subsets, resting T cells, B cells, and macrophages, and at high levels on CD4
+
CD25
+
regulatory T cells (Tregs). Upon activation, expression on CD4
+
and CD8
+
T cells is upregulated. Triggering of GITR has been described to modulate Treg function and co-stimulate effector T cells. Stimulation of T cells through GITR can abrogate the inhibitory function of Tregs. It is hypothesized that GITR has a role in the maintenance of immunological self tolerance, and mouse models of autoimmune disease suggest that GITR activation may break self-tolerance and induce autoimmunity.
Additional information: Clone REA1007 displays negligible binding to Fc receptors.

Alternative Names

TNFRSF18, AITR, GITR

Technical specifications

  • Antigen: CD357 (GITR)
  • Clone: REA1007
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TNFRSF18, AITR, GITR
  • Entrez Gene ID: 8784
  • Molecular mass of antigen [kDa]: 24
  • Distribution of antigen: B cells, macrophages, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Biotin

Related products

2 products available
Product options: 8

Product information

Size
Order no.
Price

CD357 (GITR)-PE, human

  • REA1007
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-960
-

CD357 (GITR)-PE, human

  • REA1007
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-840
-

CD357 (GITR)-APC, human

  • REA1007
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-961
-

CD357 (GITR)-APC, human

  • REA1007
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-841
-

CD357 (GITR)-PE-Vio615, human

  • REA1007
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-962
-

CD357 (GITR)-PE-Vio615, human

  • REA1007
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-842
-

CD357 (GITR)-Biotin, human

  • REA1007
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-964
-

CD357 (GITR)-Biotin, human

  • REA1007
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-844
-