CD357 (GITR) antibodies, human

CD357 (GITR) antibodies, human

Clone: DT5D3 | Dilution: 1:50
CD357, also known as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) or TNFRSF18, is an inducible type I transmembrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily.
CD357 is expressed at low levels on thymocyte subsets, resting T cells, B cells, macrophages, and at high levels on CD4
+
CD25
+
regulatory T cells (Tregs). Upon activation, expression on CD4
+
and CD8
+
T cells is upregulated. Triggering of CD357 has been described to modulate Treg function and costimulate effector T cells. Stimulation of T cells through CD357 can abrogate the inhibitory function of Tregs. It is hypothesized that CD357 has a role in the maintenance of immunological self tolerance, and mouse models of autoimmune disease suggest that CD357 activation may break self-tolerance and induce autoimmunity.

Alternative Names

TNFRSF18, AITR, GITR-D

Technical specifications

  • Antigen: CD357 (GITR)
  • Clone: DT5D3
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: TNFRSF18, AITR, GITR-D
  • Entrez Gene ID: 8784
  • Molecular mass of antigen [kDa]: 24
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE

Related products

9 products available | view all
Product options: 4

Product information

Size
Order no.
Price

CD357 (GITR)-APC, human

  • DT5D3
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-154
-

CD357 (GITR)-APC, human

  • DT5D3
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-977
-

CD357 (GITR)-PE, human

  • DT5D3
  • 1:50
  • For research use only
for 30
tests
(1)
130-121-416
-

CD357 (GITR)-PE, human

  • DT5D3
  • 1:50
  • For research use only
for 100
tests
(1)
130-121-331
-