CD357 (GITR) antibodies, human

Clone: DT5D3 | Dilution: 1:50
Glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) is an inducible Type I transmembrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily.
1
GITR is also known as TNFRSF18.
2
GITR is expressed at low levels on thymocyte subsets, resting T cells, B cells, macrophages, and at high levels on CD4
+
CD25
+
regulatory T cells (Tregs). Upon activation, expression on CD4
+
and CD8
+
T cells is upregulated. Triggering of GITR has been described to modulate Treg function and costimulate effector T cells.
3
Stimulation of T cells through GITR can abrogate the inhibitory function of Tregs. It is hypothesized that GITR has a role in the maintenance of immunological self tolerance, and mouse models of autoimmune disease suggest that GITR activation may break self-tolerance and induce autoimmunity.

Alternative Names

TNFRSF18, AITR, CD357, GITR-D

Technical specifications

  • Antigen: GITR
  • Clone: DT5D3
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: TNFRSF18, AITR, CD357, GITR-D
  • Entrez Gene ID: 8784
  • Molecular mass of antigen [kDa]: 24
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC

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