CD354 (TREM-1) antibodies, human

CD354 (TREM-1) antibodies, human

Clone: REA213 | Dilution: 1:11
Clone REA213 recognizes the human CD354 (TREM-1), a 30 KDa member of the triggering receptors expressed on myeloid cells (TREM) family of cell surface receptors. TREM receptors are immunoglobulin 'superfamily' members and contain a single variable-type immunoglobulin domain. Human TREM cluster is located on chromosome 6p21. Expression of TREM-1 is found on the cell surface of myeloid cells such as neutrophils, monocytes, dendritic cells, and macrophages. TREM-1 signals via ITAM-containing adaptor DAP12 and serves as an amplifier of cell activation in response to triggers such as LPS. TREM-1 activated cellular signalling molecules and pathways lead to generation of pro-inflammatory response such as expression and secretion of chemokines and cytokines including MCP-1, MIP-1a, IL-6, IL-8, and TNF. TREM-1 acts in a concerted manner with other signalling receptors such as TLRs and Nod-like receptors, leading to an amplification of the initial response. Expression of TREM-1 itself is upregulated in response to presence of LPS, microbial products, and cytokines released during activation response. A soluble form of TREM-1 (sTREM-1) is also detected in fluids from patients with infections.
Additional information: Clone REA213 displays negligible binding to Fc receptors.

Alternative Names

TREM1

Technical specifications

  • Antigen: CD354 (TREM-1)
  • Clone: REA213
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TREM1
  • Distribution of antigen: dendritic cells, macrophages, neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
Product options: 16

Product information

Size
Order no.
Price

CD354 (TREM-1)-FITC, human

  • REA213
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-038
-

CD354 (TREM-1)-FITC, human

  • REA213
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-040
-

CD354 (TREM-1)-PE, human

  • REA213
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-033
-

CD354 (TREM-1)-PE, human

  • REA213
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-035
-

CD354 (TREM-1)-APC, human

  • REA213
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-055
-

CD354 (TREM-1)-APC, human

  • REA213
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-050
-

CD354 (TREM-1)-VioBlue, human

  • REA213
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-018
-

CD354 (TREM-1)-VioBlue, human

  • REA213
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-020
-

CD354 (TREM-1)-PE-Vio770, human

  • REA213
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-021
-

CD354 (TREM-1)-PE-Vio770, human

  • REA213
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-023
-

CD354 (TREM-1)-APC-Vio770, human

  • REA213
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-056
-

CD354 (TREM-1)-APC-Vio770, human

  • REA213
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-051
-

CD354 (TREM-1)-PerCP-Vio700, human

  • REA213
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-029
-

CD354 (TREM-1)-PerCP-Vio700, human

  • REA213
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-026
-

CD354 (TREM-1)-Biotin, human

  • REA213
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-044
-

CD354 (TREM-1)-Biotin, human

  • REA213
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-047
-

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