CD352 (NTB-A) antibodies, human

CD352 (NTB-A) antibodies, human

Clone: REA339 | Dilution: 1:50
Clone REA339 recognizes the human CD352 antigen, a 60 kDa single-pass type I membrane protein also known as SLAM family member 6 (SLAM6) or natural killer (NK), T, and B cell–antigen (NTB-A). CD352 belongs to the CD2 subfamily of the immunoglobulin superfamily and is expressed on NK, T, and B cells. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases. Monoclonal antibody-mediated cross-linking of CD352 results in the induction of NK-mediated cytotoxicity. CD352 also triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors. This suggests that CD352 may function as a coreceptor in the process of NK cell activation. Importantly, analysis of NK cells derived from patients with X-linked lymphoproliferative disease showed that the lack of SH2D1A protein profoundly affects the function of CD352.
Additional information: Clone REA339 displays negligible binding to Fc receptors.

Alternative Names

SLAMF6, KALI, KALIb, LY108, NTB-A, NTBA, SF2000, SLAM6, TCOM

Technical specifications

  • Antigen: CD352 (NTB-A)
  • Clone: REA339
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SLAMF6, KALI, KALIb, LY108, NTB-A, NTBA, SF2000, SLAM6, TCOM
  • Entrez Gene ID: 114836
  • Molecular mass of antigen [kDa]: 35
  • Distribution of antigen: NK cells, B cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
Product options: 2

Product information

Size
Order no.
Price

CD352 (NTB-A)-PE, human

  • REA339
  • 1:50
  • For research use only
for 30
tests
(1)
130-121-127
-

CD352 (NTB-A)-PE, human

  • REA339
  • 1:50
  • For research use only
for 100
tests
(1)
130-121-051
-

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