CD35 antibodies, human

CD35 antibodies, human

Clone: REA1133 | Dilution: 1:50
Clone REA1133 recognizes the human cell surface protein CD35, the C3b/C4b receptor, also known as CR1 or complement receptor type I. Four CD35 allotypes with different molecular weights are known; 190, 220, 250, and 280 kDa. CD35 is expressed on hematopoietic cells such as granulocytes, monocytes, B cells, subsets of NK and T cells, erythrocytes, and follicular dendritic cells (DCs). Known functions of CD35 include transport of C3 complexes on erythrocytes, complement activation, phagocytosis, and inhibition of the activation-induced proliferation of T and B cells.
Additional information: Clone REA1133 displays negligible binding to Fc receptors.

Alternative Names

CR1, C3BR, C4BR, KN, C3b/C4b-R

Technical specifications

  • Antigen: CD35
  • Clone: REA1133
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CR1, C3BR, C4BR, KN, C3b/C4b-R
  • Entrez Gene ID: 1378
  • Molecular mass of antigen [kDa]: 220
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    ,
    olive baboon (
    Papio anubis
    )
  • Distribution of antigen: dendritic cells, T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, VioBright 515, Biotin
  • Selected References

    1. Reynes, M. et al. (1985) Human follicular dendritic cells express CR1, CR2, and CR3 complement receptor antigens. J. Immunol. 135: 2687-2694
    2. Klickstein, L. B. et al. (1988) Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis. J. Exp. Med. 168: 1699-1717
    3. Reilly, B. et al. (2010)
      Human peripheral CD4
      +
      T-cells expressing complement receptor 1 (CR1, CD35).
      J. Immunol. 184(1 Supplement): 138.3
Product options: 12

Product information

Size
Order no.
Price

CD35-PE, human

  • REA1133
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-625
-

CD35-PE, human

  • REA1133
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-510
-

CD35-APC, human

  • REA1133
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-626
-

CD35-APC, human

  • REA1133
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-511
-

CD35-PE-Vio615, human

  • REA1133
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-627
-

CD35-PE-Vio615, human

  • REA1133
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-512
-

CD35-PE-Vio770, human

  • REA1133
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-628
-

CD35-PE-Vio770, human

  • REA1133
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-513
-

CD35-VioBright 515, human

  • REA1133
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-631
-

CD35-VioBright 515, human

  • REA1133
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-516
-

CD35-Biotin, human

  • REA1133
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-632
-

CD35-Biotin, human

  • REA1133
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-517
-