CD35 antibodies, human

CD35 antibodies, human

Clone: E11 | Dilution: 1:11
The monoclonal antibody E11 recognizes the human cell surface protein CD35, the C3b/C4b receptor, also known as CR1 or complement receptor type I. Four CD35 allotypes with different molecular weights are known; 190, 220, 250, and 280 kDa. CD35 is expressed on hematopoietic cells such as granulocytes, monocytes, B cells, subsets of natural killer (NK) and T cells, erythrocytes, and follicular dendritic cells (DCs). Known functions of CD35 include transport of C3 complexes on erythrocytes, complement activation, phagocytosis, and inhibition of the activation-induced proliferation of T and B cells.

Alternative names

CR1, C3BR, C4BR, KN, C3b/C4b-R

Technical specifications

  • Antigen: CD35
  • Clone: E11
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CR1, C3BR, C4BR, KN, C3b/C4b-R
  • Entrez Gene ID: 1378
  • Molecular mass of antigen [kDa]: 220
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    ,
    olive baboon (
    Papio anubis
    )
  • Distribution of antigen: dendritic cells, T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Reilly, B. et al. (2010)
      Human peripheral CD4
      +
      T-cells expressing complement receptor 1 (CR1, CD35).
      J. Immunol. 184(1 Supplement): 138.3
    2. Reynes, M. et al. (1985) Human follicular dendritic cells express CR1, CR2, and CR3 complement receptor antigens. J. Immunol. 135: 2687-2694
    3. Klickstein, L. B. et al. (1988) Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis. J. Exp. Med. 168: 1699-1717
Product options: 14
130-099-913

CD35-PE, human

for 30
tests
(1)
-
130-099-922

CD35-PE, human

for 100
tests
(1)
-
130-099-923

CD35-APC, human

for 30
tests
(1)
-
130-099-930

CD35-APC, human

for 100
tests
(1)
-
130-101-613

CD35-VioBlue, human

for 30
tests
(1)
-
130-101-610

CD35-VioBlue, human

for 100
tests
(1)
-
130-099-905

CD35-PE-Vio770, human

for 30
tests
(1)
-
130-100-006

CD35-PE-Vio770, human

for 100
tests
(1)
-
130-101-617

CD35-APC-Vio770, human

for 30
tests
(1)
-
130-101-605

CD35-APC-Vio770, human

for 100
tests
(1)
-
130-101-618

CD35-PerCP-Vio700, human

for 30
tests
(1)
-
130-101-612

CD35-PerCP-Vio700, human

for 100
tests
(1)
-
130-101-624

CD35-Biotin, human

for 30
tests
(1)
-
130-101-620

CD35-Biotin, human

for 100
tests
(1)
-