CD344 (Frizzled-4) antibodies, human

CD344 (Frizzled-4) antibodies, human

Clone: CH3A4A7 | Dilution: 1:11
Clone CH3A4A7 recognizes an extracellular epitope of the human CD344 antigen, a multi-pass membrane protein which is also known as Frizzled family receptor 4 (FZD4) or Frizzled-4. CD344 is expressed by neuronal stem cells and also found on fetal neuronal progenitor cells and neuronal intestinal cells. It is a member of the Frizzled family of proteins which encode seven-transmembrane domain proteins that are receptors for the wingless-type MMTV integration site family of signaling proteins. CD344 is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). It is the only representative of frizzled family members that binds strongly an additional ligand norrin that is functionally similar but structurally different from wingless-type proteins. CD344 signaling induced by norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear.

Alternative Names

FZD4, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4

Technical specifications

  • Antigen: CD344 (Frizzled-4)
  • Clone: CH3A4A7
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: FZD4, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4
  • Entrez Gene ID: 8322
  • Molecular mass of antigen [kDa]: 56
  • Distribution of antigen: neural stem cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700
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