CD32 antibodies, human

CD32 antibodies, human

Clone: 2E1 | Dilution: 1:11
FcγRII (CD32) is a 40 kDa low affinity receptor for the Fc fragment of aggregated IgG. Due to alternative splicing three different isoforms of CD32 are expressed on hematopoietic cells: FcRIIA, FcRIIB, and FcRIIC. The cytoplasmic domains of FcRIIA and FcRIIC contain an activatory ITAM motif whereas FcRIIB is an inhibitory receptor containing an ITIM motif. Different isoforms of CD32 are expressed on B cells, monocytes, dendritic cells, granulocytes, and platelets. The monoclonal antibody 2E1 recognizes all isoforms of CD32 without blocking the binding of immune complexes.

Alternative Names

FCGR2A, FCGR2B, FCGR2C, FcγRII

Technical specifications

  • Antigen: CD32
  • Clone: 2E1
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: FCGR2A, FCGR2B, FCGR2C, FcγRII
  • Entrez Gene ID: 2212
  • Molecular mass of antigen [kDa]: 31
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    , baboon, horse
  • Distribution of antigen: B cells, basophils, dendritic cells, endothelial cells, eosinophils, granulocytes, Langerhans cells, leukocytes, lymphocytes, macrophages, monocytes, myeloid cells, neutrophils, NK cells, placenta, plasma cells, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin
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