CD314 (NKG2D) antibodies, rat

CD314 (NKG2D) antibodies, rat

Clone: REA471 | Dilution: 1:10
Clone REA471 recognizes the rat CD314 antigen, a single-pass type II membrane homodimeric glycoprotein belonging to the C-type lectin-like receptor family, which is also known as NKG2-D type II integral membrane protein (NKG2D) or killer cell lectin-like receptor subfamily K member 1 (Klrk1). Rat CD314 is expressed in NK cells, and is strongly expressed in resting CD8
+
and CD4
+
T cells, but not by thymocytes or other hemopoietic cells. It functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. CD314 provides both, stimulatory and costimulatory innate immune responses on activated killer cells, leading to cytotoxic activity. It acts as a costimulatory receptor for T cell–receptor in CD8
+
T cell–mediated adaptive immune responses by amplifying T cell–activation. Ligands of CD314 belong to various subfamilies of MHC class I–related glycoproteins.
Additional information: Clone REA471 displays negligible binding to Fc receptors.

Alternative Names

Klrk1, Nkg2d, NKLLR, NKR-P2, NKG2D

Technical specifications

  • Antigen: CD314
  • Clone: REA471
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Klrk1, Nkg2d, NKLLR, NKR-P2, NKG2D
  • Entrez Gene ID: 24934
  • Molecular mass of antigen [kDa]: 24
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
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