CD307e (FcRL5) antibodies, human

CD307e (FcRL5) antibodies, human

Clone: REA391 | Dilution: 1:11
Clone REA391 recognizes the human CD307e antigen, a 106 kDa single-pass type I membrane protein also known as Fc receptor-like protein 5 (FcRL5) or immune receptor translocation-associated protein 2 (IRTA2). CD307e possesses a cytoplasmic tail with inhibitory ITIM phosphorylation signaling motifs and was found to inhibit B cell antigen receptor signaling by recruiting SHP1 to two ITIM motifs upon B cell antigen receptor co-stimulation, resulting in diminished calcium influx and protein tyrosine phosphorylation. Co-stimulation of CD307e and the B cell antigen receptor promotes proliferation and differentiation of naive B cells. CD307e is expressed on both mature B cells and plasma cells, and is induced by EBV proteins. It is overexpressed on malignant B cells of hairy cell leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, and multiple myeloma patients. In addition, serum levels of soluble CD307e are elevated in patients with several types of B cell tumors.
Additional information: Clone REA391 displays negligible binding to Fc receptors.

Alternative Names

FCRL5, BXMAS1, CD307, FCRH5, IRTA2, PRO820

Technical specifications

  • Antigen: CD307e (FcRL5)
  • Clone: REA391
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FCRL5, BXMAS1, CD307, FCRH5, IRTA2, PRO820
  • Entrez Gene ID: 83416
  • Molecular mass of antigen [kDa]: 105
  • Distribution of antigen: B cells, plasma cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
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