CD307e (FcRL5) antibodies, human

CD307e (FcRL5) antibodies, human

Clone: REA391 | Dilution: 1:11
Clone REA391 recognizes the human CD307e antigen, a 106 kDa single-pass type I membrane protein also known as Fc receptor-like protein 5 (FcRL5) or immune receptor translocation-associated protein 2 (IRTA2). CD307e possesses a cytoplasmic tail with inhibitory ITIM phosphorylation signaling motifs and was found to inhibit B cell antigen receptor signaling by recruiting SHP1 to two ITIM motifs upon B cell antigen receptor co-stimulation, resulting in diminished calcium influx and protein tyrosine phosphorylation. Co-stimulation of CD307e and the B cell antigen receptor promotes proliferation and differentiation of naive B cells. CD307e is expressed on both mature B cells and plasma cells, and is induced by EBV proteins. It is overexpressed on malignant B cells of hairy cell leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, and multiple myeloma patients. In addition, serum levels of soluble CD307e are elevated in patients with several types of B cell tumors.
Additional information: Clone REA391 displays negligible binding to Fc receptors.

Alternative Names

FCRL5, BXMAS1, CD307, FCRH5, IRTA2, PRO820

Technical specifications

  • Antigen: CD307e (FcRL5)
  • Clone: REA391
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FCRL5, BXMAS1, CD307, FCRH5, IRTA2, PRO820
  • Entrez Gene ID: 83416
  • Molecular mass of antigen [kDa]: 105
  • Distribution of antigen: B cells, plasma cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected References

    1. Miller, I. et al. (2002) IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. Blood 99(8): 2662-2669
    2. Zhu, Z. et al. (2013) FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 110(14): E1282-E1290
    3. Nakayama, Y. et al. (2001) BXMAS1 identifies a cluster of homologous genes differentially expressed in B cells. Biochem. Biophys. Res. Commun. 285(3): 830-837
Product options: 8
130-106-043

CD307e (FcRL5)-FITC, human

for 30
tests
(1)
-
130-105-994

CD307e (FcRL5)-FITC, human

for 100
tests
(1)
-
130-106-044

CD307e (FcRL5)-PE, human

for 30
tests
(1)
-
130-105-995

CD307e (FcRL5)-PE, human

for 100
tests
(1)
-
130-106-045

CD307e (FcRL5)-APC, human

for 30
tests
(1)
-
130-105-996

CD307e (FcRL5)-APC, human

for 100
tests
(1)
-
130-106-042

CD307e (FcRL5)-Biotin, human

for 30
tests
(1)
-
130-105-993

CD307e (FcRL5)-Biotin, human

for 100
tests
(1)
-