CD304 (BDCA-4) antibodies, human

CD304 (BDCA-4) antibodies, human

Clone: AD5-17F6 | Dilution: 1:11
Clone AD5-17F6 recognizes the human CD304 (BDCA-4) antigen. Like CD303 (BDCA-2), the CD304 (BDCA-4) antigen is specifically expressed on human plasmacytoid dendritic cells in blood and bone marrow. Unlike CD303 (BDCA-2), expression of CD304 (BDCA-4) is up-regulated on plasmacytoid dendritic cells and induced on myeloid cells upon culturing. In inflamed tonsils, CD304 (BDCA-4) expression, apart from plasmacytoid dendritic cells, is also detected primarily on follicular B helper memory T cells. CD304 (BDCA-4) is identical to neuropilin-1 (NP-1), a neuronal receptor, which is known to be expressed on numerous nonhematopoietic cell types, including neurons, endothelial, and tumor cells. CD1a
+
dendritic cells generated
ex vivo
from monocytes or hematopoietic precursor cells are CD304 (BDCA-4)
+
but CD303 (BDCA-2)
.

Alternative Names

NRP1, BDCA-4, NP1, Nrp, VEGF165R

Technical specifications

  • Antigen: CD304 (BDCA-4)
  • Clone: AD5-17F6
  • Isotype: mouse IgG1
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: NRP1, BDCA-4, NP1, Nrp, VEGF165R
  • Entrez Gene ID: 8829
  • Molecular mass of antigen [kDa]: 101
  • Distribution of antigen: CNS cells, dendritic cells, endothelial cells, heart, kidney, liver, neurons, placenta, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, Biotin, pure
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