CD30 antibodies, mouse

CD30 antibodies, mouse

Clone: mCD30.1 | Dilution: 1:10
Clone mCD30.1 recognizes mouse CD30, a 105 kDa type I transmembrane glycoprotein, also known as tumor necrosis factor receptor superfamily member 8 (TNFRSF8). CD30 is a cell membrane protein. The cytoplasmic tail has been shown to interact with tumor necrosis factor receptor-associated factor 5 (TRAF5), TRAF1, TRAF2, and TRAF3. CD30 is expressed on the cell surface of activated T, B, and NK cells, and monocytes. The ligand for CD30 is CD153. CD153 co-stimulates peripheral blood T-cell proliferation or apoptosis, induces surface expression of activation and adhesion molecules (e.g., CD54, CD80, and CD86), and induces cytokine (e.g., interleukin 2, tumor necrosis factor, and interferon γ) secretion. Deletion of the murine CD30 gene revealed that CD30 may have a unique role in negative thymic selection following exposure to antigen.

Alternative names

TNFRSF8, Ki, Ki-1

Technical specifications

  • Antigen: CD30
  • Clone: mCD30.1
  • Isotype: hamster IgG1κ
  • Alternative names of antigen: TNFRSF8, Ki, Ki-1
  • Entrez Gene ID: 21941
  • Molecular mass of antigen [kDa]: 51,4
  • Distribution of antigen: T cells, B cells, NK cells, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Bowen, M. A. et al. (1996) Structure and expression of murine CD30 and its role in cytokine production. J. Immunol. 156(2): 442-449
    2. Ansieau, S. et al. (1996)
      Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact
      in vivo
      with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation.
      Proc. Natl. Acad. Sci. U.S.A. 93(24): 14053-14058
    3. Aizawa, S. et al. (1997) Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. J. Biol. Chem. 272(4): 2042-2045
Product options: 6
130-103-974

CD30-PE, mouse

9 µg in 300 µL (1)
-
130-103-942

CD30-PE, mouse

30 µg in 1 mL (1)
-
130-103-975

CD30-APC, mouse

9 µg in 300 µL (1)
-
130-103-943

CD30-APC, mouse

30 µg in 1 mL (1)
-
130-103-976

CD30-Biotin, mouse

9 µg in 300 µL (1)
-
130-103-941

CD30-Biotin, mouse

30 µg in 1 mL (1)
-