CD283 (TLR3) antibodies, mouse

CD283 (TLR3) antibodies, mouse

Clone: 11F8 | Dilution: 1:10
Clone 11F8 recognizes CD283 antigen, which is also known as toll-like receptor 3 (TLR3). Toll-like receptors are a family of pattern recognition receptors that have evolved to detect components of foreign pathogens referred to as pathogen associated molecular patterns. TLR3 is a single-pass type I membrane protein expressed exclusively in intracellular vesicles, such as the endoplasmic reticulum (ER), endosomes, lysosomes, and endolysosomes, where it recognizes microbial dsRNA. Multiple cell types are known to express TLR3 including dendritic cells, keratinocytes, and neurons. TLR3 activates antiviral immune responses via the TRIF-dependent pathway and eventually through the production of type I interferon and inflammatory cytokines, suggesting that TLR3 has an essential role in the prevention of viral infection.

Alternative names

TLR3

Technical specifications

  • Antigen: CD283 (TLR3)
  • Clone: 11F8
  • Isotype: rat IgG2a
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: TLR3
  • Entrez Gene ID: 142980
  • Molecular mass of antigen [kDa]: 101
  • Distribution of antigen: dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770
  • Selected references

    1. Doyle, S. E. et al. (2003) Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. J. Immunol. 170(7): 3565-3571
    2. Alexopoulou, L. et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413(6587): 732-738
    3. Applequist, S. E. et al. (2002) Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines. Int. Immunol. 14(9): 1065-1074
Product options: 8
130-103-397

CD283 (TLR3)-FITC, mouse

9 µg in 300 µL (1)
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130-102-758

CD283 (TLR3)-FITC, mouse

30 µg in 1 mL (1)
-
130-103-398

CD283 (TLR3)-PE, mouse

9 µg in 300 µL (1)
-
130-102-759

CD283 (TLR3)-PE, mouse

30 µg in 1 mL (1)
-
130-103-399

CD283 (TLR3)-APC, mouse

9 µg in 300 µL (1)
-
130-102-760

CD283 (TLR3)-APC, mouse

30 µg in 1 mL (1)
-
130-103-400

CD283 (TLR3)-PE-Vio770, mouse

9 µg in 300 µL (1)
-
130-102-761

CD283 (TLR3)-PE-Vio770, mouse

30 µg in 1 mL (1)
-