CD282 (TLR2) antibodies, human and mouse

CD282 (TLR2) antibodies, human and mouse

Clone: REA109
Clone REA109 recognises human and mouse CD282, also known as toll-like receptor 2 (TLR2). TLRs are the host pattern recognition receptors involved in recognising pathogen associated and certain tissue damage indicating molecules. They are type 1 transmembrane proteins with extracellular leucine-rich repeats and intracellular toll/IL-1 receptor domains. TLR2 is a plasma membrane associated TLR and recognizes various structurally diverse molecules including peptidoglycans (PG), lipopeptides and lipoproteins moieties in Gram
+
and Gram
bacteria, lipoteichoic acid (LTA) in Gram
+
bacteria, lipoarabinomannan and lipomannan from Mycoplasma, and fungal polysaccharides such as zymogen. High-resolution crystal structures suggested that TLR2 by forming heterodimers with TLR6 and TLR1 can distinguish between di-acylated and tri-acylated lipopeptides. The expression of CD282 (TLR2) is found on monocytes, granulocytes, dendritic, endothelial, and epithelial cells.
Additional information: Clone REA109 displays negligible binding to Fc receptors.

Alternative Names

TLR2, TIL4, Ly105

Technical specifications

  • Antigen: CD282 (TLR2)
  • Clone: REA109
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TLR2, TIL4, Ly105
  • Entrez Gene ID: 7097
  • Molecular mass of antigen [kDa]: 88
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
Product options: 1

Product information

Size
Order no.
Price

CD282 (TLR2) pure, human and mouse

  • REA109
  • For research use only
100 µg in 100 µL
130-108-058
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