CD278 (ICOS) antibodies, mouse

CD278 (ICOS) antibodies, mouse

Clone: 7E.17G9 | Dilution: 1:10
Clone 7E.17G9 reacts with CD278, the inducible co-stimulatory molecule (ICOS), a 47–57 kDa homodimeric glycoprotein of the CD28 family. Directly
ex vivo
, CD278 is expressed only by a small subset of T cells, including follicular B helper T cells (TFH) and regulatory T cells. However, CD278 is strongly up-regulated on the surface following T cell activation. Upon binding to its ligand (ICOSL), CD278 initiates a multitude of events, which modulate many different aspects of T cell–mediated immune responses. Besides regulating differentiation and activation of effector as well as regulatory CD4
+
T cells, ICOS also plays a role in germinal center formation and isotype switching.

Alternative Names

ICOS, AILIM, CCLP, CRP-1, H4, Ly115

Technical specifications

  • Antigen: CD278 (ICOS)
  • Clone: 7E.17G9
  • Isotype: rat IgG2bκ
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: ICOS, AILIM, CCLP, CRP-1, H4, Ly115
  • Entrez Gene ID: 54167
  • Molecular mass of antigen [kDa]: 20
  • Distribution of antigen: B cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
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