CD278 (ICOS) antibodies, human, mouse, rat

CD278 (ICOS) antibodies, human, mouse, rat

Clone: REA192 | Dilution: 1:50
Clone REA192 recognizes CD278 (ICOS), which belongs to the CD28 family of proteins. CD28 family members are co-stimulatory receptor molecules, contain single immunoglobulin V-like domain, and belong to the immunoglobulin superfamily. CD287 recognizes ICOSL (inducible T cell co-stimulator ligand) as ligand and its expression is induced on activated T cells. Enhanced expression of CD278 is also observed on T cells, followed by co-stimulation of T cells via CD28. Further expression of CD278 is found on B cells, monocytes, and dendritic cells. Crosslinking of ICOS on T cell surface in the presence of primary stimulation signal leads to T cell proliferation and differentiation. In addition, CD278 plays role in Tʜ cell differentiation, effector T cell function, and isotype class switching.
Additional information: Clone REA192 displays negligible binding to Fc receptors.

Alternative Names

ICOS, AILIM, CVID1

Technical specifications

  • Antigen: CD278 (ICOS)
  • Clone: REA192
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ICOS, AILIM, CVID1
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected References

    1. Akbari, O. et al. (2008)
      ICOS/ICOSL interaction is required for CD4
      +
      invariant NKT cell function and homeostatic survival
      J. Immunol. 180: 5448-5456
    2. Wassink, L. et al. (2004) ICOS expression by activated human Tʜ Cells is enhanced by IL-12 and IL-23: Increased ICOS expression enhances the effector function of both Tʜ1 and Tʜ2 cells. J. Immunol. 173: 1779-1786
Product options: 2

Product information

Size
Order no.
Price

CD278 (ICOS)-PE, human, mouse, rat

  • REA192
  • 1:50
  • For research use only
for 30
tests
(1)
130-120-155
-

CD278 (ICOS)-PE, human, mouse, rat

  • REA192
  • 1:50
  • For research use only
for 100
tests
(1)
130-120-069
-