CD275 (B7-H2) antibodies, human

CD275 (B7-H2) antibodies, human

Clone: REA991 | Dilution: 1:50
Clone REA991 recognizes the human CD275 antigen, aslo known as B7-H2, ICOSL, or GL50, a member of the B7 family of co-stimulatory molecules involved in regulating T cell activation and effector functions. It belongs to the Ig superfamily and has a predicted molecular weight of 40 kDa. CD275 is a ligand of inducible co-stimulator (ICOS) expressed on activated T cells. ICOS mediated co-stimulation promotes T helper (Tʜ) cell differentiation via Tʜ2 cytokine production such as interleukin 10 (IL-10) and IL-4. Human CD275 is expressed on B cells, dendritic cells, endothelial cells, renal tubular epithelial cells, activated monocytes, and human airway epithelial cells.
Additional information: Clone REA991 displays negligible binding to Fc receptors.

Alternative Names


Technical specifications

  • Antigen: CD275 (B7-H2)
  • Clone: REA991
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ICOSLG, B7-H2, B7H2, B7RP-1, GL50, ICOSL, LICOS
  • Entrez Gene ID: 23308
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, epithelial cells, monocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, VioBright 515
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