CD275 (B7-H2) antibodies, human

CD275 (B7-H2) antibodies, human

Clone: MIH12 | Dilution: 1:11
Clone MIH12 recognizes CD275 (B7-H2, ICOSL, GL50), a member of the B7 family of costimulatory molecules involved in regulating T cell activation and effector functions. It belongs to Ig superfamily and has a predicted molecular weight of 40 kDa. CD275 is a ligand of inducible costimulator (ICOS) expressed on activated T cells. ICOS mediated costimulation promotes T-helper cell differentiation via Tʜ2 cytokine production such as IL-10 and IL-4. Human CD275 is expressed on B cells, dendritic cells, endothelial cells, renal tubular epithelial cells, activated monocytes, and human airway epithelial cells.

Alternative Names


Technical specifications

  • Antigen: CD275 (B7-H2)
  • Clone: MIH12
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: ICOSLG, B7-H2, B7H2, B7RP-1, GL50, ICOSL, LICOS
  • Entrez Gene ID: 23308
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, epithelial cells, monocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
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