CD275 (B7-H2) antibodies, human

CD275 (B7-H2) antibodies, human

Clone: MIH12 | Dilution: 1:11
Clone MIH12 recognizes CD275 (B7-H2, ICOSL, GL50), a member of the B7 family of costimulatory molecules involved in regulating T cell activation and effector functions. It belongs to Ig superfamily and has a predicted molecular weight of 40 kDa. CD275 is a ligand of inducible costimulator (ICOS) expressed on activated T cells. ICOS mediated costimulation promotes T-helper cell differentiation via Tʜ2 cytokine production such as IL-10 and IL-4. Human CD275 is expressed on B cells, dendritic cells, endothelial cells, renal tubular epithelial cells, activated monocytes, and human airway epithelial cells.

Alternative Names

ICOSLG, B7-H2, B7H2, B7RP-1, GL50, ICOSL, LICOS

Technical specifications

  • Antigen: CD275 (B7-H2)
  • Clone: MIH12
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: ICOSLG, B7-H2, B7H2, B7RP-1, GL50, ICOSL, LICOS
  • Entrez Gene ID: 23308
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, epithelial cells, monocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
  • Selected References

    1. Kurosawa, S. et al. (2003) Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 28: 563-573
    2. Wang, S. et al. (2000) Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 96(8): 2808-2813
    3. Qian, X. et al. (2006) The ICOS-ligand B7-H2, expessed on human type II alveolar epithelial cells, plays a role in the pulmonary host defense system. Eur. J. Immunol. 36(4): 906-918
Product options: 10

Product information

Size
Order no.
Price

CD275 (B7-H2)-FITC, human

  • MIH12
  • 1:11
  • For research use only
for 30
tests
(1)
130-098-732
-

CD275 (B7-H2)-FITC, human

  • MIH12
  • 1:11
  • For research use only
for 100
tests
(1)
130-098-730
-

CD275 (B7-H2)-PE, human

  • MIH12
  • 1:11
  • For research use only
for 30
tests
(1)
130-098-735
-

CD275 (B7-H2)-PE, human

  • MIH12
  • 1:11
  • For research use only
for 100
tests
(1)
130-098-733
-

CD275 (B7-H2)-APC, human

  • MIH12
  • 1:11
  • For research use only
for 30
tests
(1)
130-098-738
-

CD275 (B7-H2)-APC, human

  • MIH12
  • 1:11
  • For research use only
for 100
tests
(1)
130-098-737
-

CD275 (B7-H2)-PE-Vio770, human

  • MIH12
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-629
-

CD275 (B7-H2)-PE-Vio770, human

  • MIH12
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-628
-

CD275 (B7-H2)-Biotin, human

  • MIH12
  • 1:11
  • For research use only
for 30
tests
(1)
130-098-728
-

CD275 (B7-H2)-Biotin, human

  • MIH12
  • 1:11
  • For research use only
for 100
tests
(1)
130-098-726
-