CD270 (HVEM) antibodies, mouse

CD270 (HVEM) antibodies, mouse

Clone: REA275 | Dilution: 1:10
Clone REA275 recognizes the CD270 antigen, a type I transmembrane protein of the TNF-receptor superfamily which is also known as Herpes virus entry mediator (HVEM) or tumor necrosis factor receptor like 2 (TR2). CD270 is expressed in multiple tissues and cell lines and shows a constitutive and relatively high expression in peripheral blood T cells, B cells, monocytes, neutrophils and dendritic cells. Both human and mouse forms of CD270 can mediate entry of herpes simplex virus-1 and -2 (HSV-1 and HSV-2). CD270 transmits both activating and inhibitory signals; e.g interaction with receptors such as BTLA or CD160 attenuates TCR-mediated signaling, whereas interaction with receptor LIGHT allows co-stimulation of T and B cells.
Additional information: Clone REA275 displays negligible binding to Fc receptors.

Alternative Names

TNFRSF14, ATAR, HVEA, HVEM, Tnfrs14

Technical specifications

  • Antigen: CD270 (HVEM)
  • Clone: REA275
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TNFRSF14, ATAR, HVEA, HVEM, Tnfrs14
  • Entrez Gene ID: 230979
  • Molecular mass of antigen [kDa]: 26
  • Distribution of antigen: B cells, T cells, monocytes, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
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