CD27 antibodies, human and mouse

CD27 antibodies, human and mouse

Clone: REA499 | Dilution: 1:11
Clone REA499 recognizes the human and mouse CD27 antigen, a single-pass type I membrane protein, also known as tumor necrosis factor receptor superfamily member 7 (TNFRSF7). CD27 is a member of the nerve growth factor receptor family and is exclusively expressed on cells of the lymphoid lineage, mostly in an activation-specific manner, and all enhance T cell receptor (TCR)-induced T cell expansion. CD27 and its ligand, CD70, have been defined at the protein, cDNA, and genomic level in both human and mouse. It is found on NK, T, and B cell populations. In human and mice, the majority of CD4
and CD8
naive peripheral T cells express CD27 and expression is up-regulated upon TCR stimulation. Loss of CD27 expression is irreversible and seems to represent terminal effector T cell differentiation. In humans, naive B cells lack CD27 but antigen receptor stimulation induces expression. CD27
B cells display all the functional and phenotypic characteristics of memory cells.
Additional information: Clone REA499 displays negligible binding to Fc receptors.

Alternative Names

S152, TNFRSF7, Tp55, T14

Technical specifications

  • Antigen: CD27
  • Clone: REA499
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: S152, TNFRSF7, Tp55, T14
  • Entrez Gene ID: 939, 21940
  • Molecular mass of antigen [kDa]: 27, 26
  • Distribution of antigen: B cells, NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, APC-Vio770, Biotin
Product options: -

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