CD269 (BCMA) antibodies, human

CD269 (BCMA) antibodies, human

Clone: REA315 | Dilution: 1:11
Clone REA315 recognizes the human CD269 antigen, a single-pass type III membrane protein which is also known as B cell maturation antigen (BCMA). CD269 is a member of the TNF-receptor superfamily that is preferentially expressed in mature B lymphocytes. It is the receptor for CD256 (TNFSF13, APRIL) and CD257 (TNFSF13B, BLyS, BAFF). CD269 promotes B cell survival and plays a role in the regulation of humoral immunity. Binding of CD269 to CD257 blocks the binding of CD257 to its receptor on the plasma membrane and inhibits CD257-triggered B lymphocyte costimulation. Overexpression of CD269 activates NF-κB and JNK, and this activation is potentiated by CD257.
Additional information: Clone REA315 displays negligible binding to Fc receptors.

Alternative Names

TNFRSF17, Bcm, BCMA

Technical specifications

  • Antigen: CD269 (BCMA)
  • Clone: REA315
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TNFRSF17, Bcm, BCMA
  • Entrez Gene ID: 608
  • Molecular mass of antigen [kDa]: 20
  • Distribution of antigen: lymphocytes, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, Biotin
  • Selected References

    1. Yu, G. et al. (2000) APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat. Immunol. 1(3): 252-256
    2. Shu, H. B. et al. (2000) B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. Proc. Natl. Acad. Sci. U.S.A. 97(16): 9156-9161
    3. Laabi, Y. et al. (1994) The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed. Nucleic Acids Res. 22(7): 1147-1154

Related products

1 products available
Product options: 2

Product information

Size
Order no.
Price

CD269 (BCMA)-Biotin, human

  • REA315
  • 1:11
  • For research use only
for 30
tests
(1)
130-104-549
-

CD269 (BCMA)-Biotin, human

  • REA315
  • 1:11
  • For research use only
for 100
tests
(1)
130-104-500
-