CD246 (ALK) antibodies, human

CD246 (ALK) antibodies, human

Clone: REA425 | Dilution: 1:10
Clone REA425 recognizes both the normal human CD246 and the nucleolar protein nucleophosmin-CD246 (NPM-CD246) chimeric antigen. CD246 is a single-pass type I membrane protein which is also known as anaplastic lymphoma kinase (ALK). It is a neuronal orphan receptor tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-CD246 gene. CD246 plays an important role in the genesis and differentiation of the nervous system. It is essentially and transiently expressed in specific regions of the central and peripheral nervous systems. CD246 is also expressed in the small intestine and testis, but not in normal lymphoid cells. It transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase pathway. Anaplastic large cell lymphoma (ALCL) is a heterogeneous group of diseases by morphology, phenotype, genotype, and clinical presentation. The production of the fusion product NPM-CD246, which is associated with ALCL, is a result of the t(2;5)(p23;q35) chromosomal translocation.
Additional information: Clone REA425 displays negligible binding to Fc receptors.

Alternative Names

ALK, NBLST3

Technical specifications

  • Antigen: CD246 (ALK)
  • Clone: REA425
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: ALK, NBLST3
  • Entrez Gene ID: 238
  • Molecular mass of antigen [kDa]: 175
  • Distribution of antigen: small intestine, testicle, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected references

    1. Morris, S. W. et al. (1994) Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263(5151): 1281-1284
    2. Tennstedt, P. et al. (2014) Patterns of ALK expression in different human cancer types. J. Clin. Pathol. 67(6): 477-481
    3. Iwahara, T. et al. (1997) Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene 14(4): 439-449
Product options: 8
130-106-492

CD246 (ALK)-FITC, human

for 30
tests
(1)
-
130-106-444

CD246 (ALK)-FITC, human

for 100
tests
(1)
-
130-106-493

CD246 (ALK)-PE, human

for 30
tests
(1)
-
130-106-445

CD246 (ALK)-PE, human

for 100
tests
(1)
-
130-106-494

CD246 (ALK)-APC, human

for 30
tests
(1)
-
130-106-446

CD246 (ALK)-APC, human

for 100
tests
(1)
-
130-112-768

CD246 (ALK)-Biotin, human

for 30
tests
(1)
-
130-112-579

CD246 (ALK)-Biotin, human

for 100
tests
(1)
-