CD244.1 antibodies, mouse

CD244.1 antibodies, mouse

Clone: REA524 | Dilution: 1:10
Clone REA524 recognizes an alloantigen of the mouse CD244 antigen, a single-pass type I membrane protein, which is also known as 2B4. CD244 is a receptor belonging to the CD2 subfamily of the Ig superfamily and is involved in non-MHC dependent cytotoxicity. Expression of CD244 is found on all NK cells, γδ T cells, basophils, and monocytes as well as a subset of memory-phenotype CD8
αβ T cells. The ligand of CD244 is CD48, which is expressed on all hematopoietic cells. CD244 is primarily involved in inhibiting NK cell functions. In inbred mice, at least two splice variants exist that differ in the length of the cytoplasmic domain. The long form functions in an inhibitory manner, while the short form functions in an activating manner. Clone REA524 reacts with CD244.1, the CD244 alloantigen which is expressed on most inbred mouse strains except C57BL/6 and C58, which express the CD244.2 allotype.
Additional information: Clone REA524 displays negligible binding to Fc receptors.

Alternative Names

2B4, NKR2B4, 2B4 B6 Alloantigen, SLAMF4

Technical specifications

  • Antigen: CD244.1
  • Clone: REA524
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: 2B4, NKR2B4, 2B4 B6 Alloantigen, SLAMF4
  • Entrez Gene ID: 18106
  • Molecular mass of antigen [kDa]: 43
  • Distribution of antigen: monocytes, NK cells, T cells, basophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, Biotin
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