CD221 (IGF-1R) antibodies, human

CD221 (IGF-1R) antibodies, human

Clone: REA271 | Dilution: 1:11
Clone REA271 recognizes human CD221 (IGF-1R), a widely expressed cell-surface glycoprotein composed of two α subunits and two β subunits. Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain. The α chains are located extracellularly, while the β subunits span the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF-1R is activated by binding of its ligands insulin-like growth factor 1 (IGF-1), IGF-2, as well as insulin to the extracellular α subunits. Ligand binding leads to autophosphorylation of tyrosine residues in the cytoplasmic regions of the receptor β subunits and subsequent recruitment and phosphorylation of insulin receptor substrate (IRS) proteins. This finally results in activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells exhibit altered IGF-1R expression.
Additional information: Clone REA271 displays negligible binding to Fc receptors.

Alternative Names


Technical specifications

  • Antigen: CD221 (IGF-1R)
  • Clone: REA271
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IGF1R, IGFIR, IGFR, JTK13
  • Entrez Gene ID: 3480
  • Molecular mass of antigen [kDa]: 151
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
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