CD207 (Langerin) antibodies, human

CD207 (Langerin) antibodies, human

Clone: REA770 | Dilution: 1:50
Clone REA770 recognizes the CD207 antigen, a 40 kDa glycosylated type II transmembrane C-type lectin receptor, and the standard marker for human and murine Langerhans cells (LCs). LCs are a subset of dendritic cells (DCs) that reside in epithelia; the best studied example of these antigen-presenting cells are LCs of the epidermis. CD207 is directly involved in antigen capture as well as endocytosis and induces the formation of typical Birbeck granules in immature DCs.
Additional information: Clone REA770 displays negligible binding to Fc receptors.

Alternative Names

CLEC4K, Langerin

Technical specifications

  • Antigen: CD207 (Langerin)
  • Clone: REA770
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CLEC4K, Langerin
  • Entrez Gene ID: 50489
  • Molecular mass of antigen [kDa]: 37
  • Distribution of antigen: Langerhans cells, epithelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio615, PE-Vio770, APC-Vio770, VioBright 515, Biotin
  • Selected References

    1. Geissmann, F. et al. (1998) Transforming growth factor β1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells J. Exp. Med. 187(6): 961-996
    2. Valladeau, J. et al. (2000) Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12(1): 71-81
    3. Rozis, G. et al. (2008) Human Langerhans cells and dermal-type dendritic cells generated from CD34 stem cells express different toll-like receptors and secrete different cytokines in response to toll-like receptor ligands Immunology 124(3): 329-338
    4. Romani, N. et al. (2010) Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol. Rev. 234(1): 120-141
    5. Stoitzner, P. et al. (2010) Isolation of skin dendritic cells from mouse and man. Methods Mol. Biol. 595: 235-248
Product options: 18

Product information

Size
Order no.
Price

CD207 (Langerin)-FITC, human

  • REA770
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-367
-

CD207 (Langerin)-FITC, human

  • REA770
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-210
-

CD207 (Langerin)-PE, human

  • REA770
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-368
-

CD207 (Langerin)-PE, human

  • REA770
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-211
-

CD207 (Langerin)-APC, human

  • REA770
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-369
-

CD207 (Langerin)-APC, human

  • REA770
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-212
-

CD207 (Langerin)-VioBlue, human

  • REA770
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-374
-

CD207 (Langerin)-VioBlue, human

  • REA770
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-217
-

CD207 (Langerin)-PE-Vio615, human

  • REA770
  • 1:50
  • For research use only
for 30
tests
(1)
130-114-428
-

CD207 (Langerin)-PE-Vio615, human

  • REA770
  • 1:50
  • For research use only
for 100
tests
(1)
130-114-321
-

CD207 (Langerin)-PE-Vio770, human

  • REA770
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-370
-

CD207 (Langerin)-PE-Vio770, human

  • REA770
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-213
-

CD207 (Langerin)-APC-Vio770, human

  • REA770
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-371
-

CD207 (Langerin)-APC-Vio770, human

  • REA770
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-214
-

CD207 (Langerin)-VioBright 515, human

  • REA770
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-373
-

CD207 (Langerin)-VioBright 515, human

  • REA770
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-216
-

CD207 (Langerin)-Biotin, human

  • REA770
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-366
-

CD207 (Langerin)-Biotin, human

  • REA770
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-209
-