CD205 (DEC205) antibodies, human

CD205 (DEC205) antibodies, human

Clone: REA1080 | Dilution: 1:50
Clone REA1080 recognizes the human CD205 (DEC205) antigen, a glycoprotein also known as Ly-75. CD205 is a 210 kDa C-type lectin single-pass membrane protein (type I), which is highly expressed on thymic epithelial cells and dendritic cells. Unlike murine CD205, human CD205 is also found at low levels on other peripheral blood lymphocytes, eg., monocytes, T cells, B cells, and NK cells. CD205 belongs to the macrophage mannose receptor family and acts as an endocytic receptor to uptake antigens, direct the captured antigens from the extracellular space to the antigen-processing compartment for antigen presentation on MHC class II and cross-presentation on MHC class I molecules. Another function of CD205 is the clearance of apoptotic cells, potentially an important pathway for the uptake of self-antigen in intrathymic and peripheral tolerance.
Additional information: Clone REA1080 displays negligible binding to Fc receptors.

Alternative Names

LY75, CLEC13B, DEC-205, GP200-MR6, LY-75

Technical specifications

  • Antigen: CD205 (DEC205)
  • Clone: REA1080
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LY75, CLEC13B, DEC-205, GP200-MR6, LY-75
  • Entrez Gene ID: 4065
  • Molecular mass of antigen [kDa]: 195
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: dendritic cells, epithelial cells, B cells, lymphocytes, T cells, NK cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, VioBright 515
  • Selected References

    1. Guo, M. et al. (2000) A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Hum. Immunol. 61(8): 729-738
    2. Bonifaz, L. et al. (2004)
      In vivo
      targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination.
      J. Exp. Med. 199: 815-824
    3. Heath, W. et al. (2004) Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol. Rev. 199: 9-26
    4. Shrimpton, R. et al. (2009) CD205 (DEC-205): A recognition receptor for apoptotic and necrotic self. Mol. Immunol. 46(6): 1229-1239
Product options: 8

Product information

Size
Order no.
Price

CD205 (DEC205)-PE, human

  • REA1080
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-752
-

CD205 (DEC205)-PE, human

  • REA1080
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-630
-

CD205 (DEC205)-APC, human

  • REA1080
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-753
-

CD205 (DEC205)-APC, human

  • REA1080
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-631
-

CD205 (DEC205)-PE-Vio615, human

  • REA1080
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-754
-

CD205 (DEC205)-PE-Vio615, human

  • REA1080
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-632
-

CD205 (DEC205)-VioBright 515, human

  • REA1080
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-757
-

CD205 (DEC205)-VioBright 515, human

  • REA1080
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-635
-