CD203c antibodies, human

CD203c antibodies, human

Clone: REA826 | Dilution: 1:50
Clone REA826 recognizes the human CD203c antigen, a glycosylated type II transmembrane molecule that belongs to the family of ecto-nucleotide pyrophosphatase/ phosphodiesterase (E-NPP3) enzymes. Among hematopoietic cells, expression of CD203c is restricted to basophils, mast cells, and their precursors, and has been described as specific for this lineage. Protein and/or mRNA expression of CD203c has also been found in solid tissues such as uterus or prostate. Basophils and mast cells are key producers of mediators that drive the onset of inflammatory responses, e.g., in allergy. Allergen challenge leads to a rapid up-regulation of activation markers such as CD203c or CD63. Due to its restricted expression pattern, CD203c is discussed as a specific marker to monitor the allergen-induced activation of basophils, e.g., in flow cytometric basophil activation tests of the peripheral blood.
Additional information: Clone REA826 displays negligible binding to Fc receptors.

Alternative Names

ENPP3, B10, NPP3, PD-IBETA, PDNP3, E-NPP3, PD-1b

Technical specifications

  • Antigen: CD203c
  • Clone: REA826
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ENPP3, B10, NPP3, PD-IBETA, PDNP3, E-NPP3, PD-1b
  • Entrez Gene ID: 5169
  • Molecular mass of antigen [kDa]: 100
  • Distribution of antigen: basophils, liver, mast cells, myeloid cells, pancreas, small intestine
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, Biotin
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