CD201 (EPCR) antibodies, human

CD201 (EPCR) antibodies, human

Clone: REA337 | Dilution: 1:11
Clone REA337 recognizes the human CD201 antigen, a single-pass type I membrane protein which is also known as endothelial protein C receptor (EPCR). CD201 is strongly expressed in the endothelial cells of arteries and veins in heart and lung, and less intensely in capillaries in the lung and skin. It is also expressed on a subset of neutrophils, monocytes, and several tumor cells. The major role of CD201 is anticoagulation. CD201 binds to protein C with high affinity and augments the activation of protein C by the thrombin-thrombomodulin complex. Another important functional aspect of CD201 is its role in many pathophysiologic processes, such as inflammation responses to infection, trauma, hematopoiesis, and autoimmune response. Mutations in the CD201 gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
Additional information: Clone REA337 displays negligible binding to Fc receptors.

Alternative Names

Procr, CCCA, CCD41, EPCR

Technical specifications

  • Antigen: CD201 (EPCR)
  • Clone: REA337
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Procr, CCCA, CCD41, EPCR
  • Entrez Gene ID: 10544
  • Molecular mass of antigen [kDa]: 25
  • Distribution of antigen: endothelial cells, heart, lung, skin, leukocytes, monocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected References

    1. Iwasaki, H. et al. (2010) Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver. Blood 116(4): 544-553
    2. Sturn, D. H. et al. (2003) Expression and function of the endothelial protein C receptor in human neutrophils. Blood 102(4): 1499-1505
    3. Willcox, C. R. et al. (2012) Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor. Nat. Immunol. 13(9): 872-879
    4. Fukudome, K. et al. (1994) Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J. Biol. Chem. 269(42): 26486-26491
Product options: 12

Product information

Size
Order no.
Price

CD201 (EPCR)-FITC, human

  • REA337
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-297
-

CD201 (EPCR)-FITC, human

  • REA337
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-255
-

CD201 (EPCR)-PE, human

  • REA337
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-298
-

CD201 (EPCR)-PE, human

  • REA337
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-256
-

CD201 (EPCR)-APC, human

  • REA337
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-299
-

CD201 (EPCR)-APC, human

  • REA337
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-257
-

CD201 (EPCR)-PE-Vio770, human

  • REA337
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-300
-

CD201 (EPCR)-PE-Vio770, human

  • REA337
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-258
-

CD201 (EPCR)-APC-Vio770, human

  • REA337
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-301
-

CD201 (EPCR)-APC-Vio770, human

  • REA337
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-259
-

CD201 (EPCR)-Biotin, human

  • REA337
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-296
-

CD201 (EPCR)-Biotin, human

  • REA337
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-254
-