CD1c (BDCA-1) antibodies, human

CD1c (BDCA-1) antibodies, human

Clone: REA694 | Dilution: 1:50
Clone REA694 recognizes the human CD1c antigen, also known as BDCA-1. CD1c is expressed on a major subpopulation of human myeloid dendritic cells (about 0.3% of blood leukocytes). Blood CD1c (BDCA-1)
+
myeloid dendritic cells are CD11c
high
, CD123
low
, CD4
+
, Lin
, CD45RO
+
, CD2
+
, CD16
, CD141 (BDCA-3)
low
, CD303 (BDCA-2)
, and CD304 (BDCA-4/Neuropilin-1)
. They express myeloid markers (CD13, CD33) as well as Fc receptors (CD32, CD64, FcεRI) and are of monocytoid appearance. A minor proportion of CD1c (BDCA-1)
+
myeloid dendritic cells expresses CD14 and CD11b. In blood, CD1c (BDCA-1) is also expressed on a subpopulation of CD19
+
small resting B lymphocytes. CD1c (BDCA-1) expression has also been detected on cortical thymocytes, on Langerhans cells, and on CD1a
+
dendritic cells generated
ex vivo
from monocytes or hematopoietic precursor cells. CD1c (BDCA-1)
+
myeloid dendritic cells have been designated as type-1 myeloid dendritic cells (MDC1s). The CD1c antigen is a member of the CD1 family of proteins that are structurally related to MHC class I proteins and mediate the presentation of non-peptide antigens to T cells.
Additional information: Clone REA694 displays negligible binding to Fc receptors.

Alternative Names

BDCA-1, CD1, R7, M241, T6, CD1a

Technical specifications

  • Antigen: CD1c (BDCA-1)
  • Clone: REA694
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: BDCA-1, CD1, R7, M241, T6, CD1a
  • Entrez Gene ID: 911
  • Molecular mass of antigen [kDa]: 36
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: dendritic cells, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, Biotin
Product options: 10

Product information

Size
Order no.
Price

CD1c (BDCA-1)-VioBright FITC, human

  • REA694
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-598
-

CD1c (BDCA-1)-VioBright FITC, human

  • REA694
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-540
-

CD1c (BDCA-1)-PE, human

  • REA694
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-594
-

CD1c (BDCA-1)-PE, human

  • REA694
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-536
-

CD1c (BDCA-1)-APC, human

  • REA694
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-595
-

CD1c (BDCA-1)-APC, human

  • REA694
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-537
-

CD1c (BDCA-1)-PE-Vio770, human

  • REA694
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-596
-

CD1c (BDCA-1)-PE-Vio770, human

  • REA694
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-538
-

CD1c (BDCA-1)-Biotin, human

  • REA694
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-593
-

CD1c (BDCA-1)-Biotin, human

  • REA694
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-535
-

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