CD1c (BDCA-1) antibodies, human

CD1c (BDCA-1) antibodies, human

Clone: AD5-8E7
The clone AD5-8E7 recognizes human CD1c, also known as BDCA-1. CD1c is expressed on a major subpopulation of human myeloid dendritic cells (about 0.3% of blood leukocytes). Blood CD1c (BDCA-1)
+
myeloid dendritic cells are CD11c
high
, CD123
low
, CD4
+
, Lin
, CD45RO
+
, CD2
+
, CD16
, CD141 (BDCA-3)
low
, CD303 (BDCA-2)
, and CD304 (BDCA-4/Neuropilin-1)
. They express myeloid markers (CD13, CD33) as well as Fc receptors (CD32, CD64, FcεRI) and are of monocytoid appearance. A minor proportion of CD1c (BDCA-1)
+
myeloid dendritic cells expresses CD14 and CD11b. In blood, CD1c (BDCA-1) is also expressed on a subpopulation of CD19
+
small resting B lymphocytes. CD1c (BDCA-1) expression has also been detected on cortical thymocytes, on Langerhans cells, and on CD1a
+
dendritic cells generated
ex vivo
from monocytes or hematopoietic precursor cells. CD1c (BDCA-1)
+
myeloid dendritic cells have been designated as type-1 myeloid dendritic cells (MDC1s).
The CD1c antigen is a member of the CD1 family of proteins that are structurally related to MHC class I proteins and mediate the presentation of non-peptide antigens to T cells.

Alternative Names

BDCA-1, CD1, CD1a, R7, M241, T6

Technical specifications

  • Antigen: CD1c (BDCA-1)
  • Clone: AD5-8E7
  • Isotype: mouse IgG2a
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: BDCA-1, CD1, CD1a, R7, M241, T6
  • Entrez Gene ID: 911
  • Molecular mass of antigen [kDa]: 36
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: B cells, dendritic cells, Langerhans cells, lymphocytes, macrophages, monocytes, myeloid leukemia cells, T cells, thymocytes
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
Product options: 1

Product information

Size
Order no.
Price

CD1c (BDCA-1) pure, human

  • AD5-8E7
  • For research use only
100 µg in 100 µL
130-108-032
-