CD199 (CCR9) antibodies, human

CD199 (CCR9) antibodies, human

Clone: REA469 | Dilution: 1:11
Clone REA469 recognizes the human CD199 antigen, a multi-pass membrane protein which is also known as C-C chemokine receptor type 9 (CCR9) or G-protein coupled receptor 28 (GPR28). CD199 is a receptor for the chemokine thymus-expressed chemokine (TECK) and a member of the G protein coupled receptor family (GPCR). The main function of GPCR family members is to send signals into the cell after the activation of G-proteins and they are known for their roles in inflammation, leukocyte trafficking, and immune differentiation. CD199 subsequently transduces a signal by increasing the intracellular calcium ions level. It influences T cell development at several stages within the thymus. In peripheral blood, CD199 is expressed by naive CD8
+
T cells, but not by naive CD4
+
T cells. It is furthermore selectively expressed on plasmacytoid dendritic cells of immature phenotype
in vivo
. Different studies have shown the involvement of the CD199-TECK axis in colorectal, prostate, ovarian, and breast cancers.
Additional information: Clone REA469 displays negligible binding to Fc receptors.

Alternative Names

CCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28

Technical specifications

  • Antigen: CD199 (CCR9)
  • Clone: REA469
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28
  • Entrez Gene ID: 10803
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: dendritic cells, T cells, thymocytes, T helper cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
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