CD195 (CCR5) antibodies, mouse

CD195 (CCR5) antibodies, mouse

Clone: REA354 | Dilution: 1:50
Clone REA354 recognizes the mouse CD195 antigen, a multi-pass membrane protein which is also known as C-C chemokine receptor type 5 (CCR5). CD195 belongs to the G-protein coupled receptor 1 family and is predominantly expressed on T cells, macrophages, dendritic cells, and microglia. It is a receptor for a number of inflammatory CC-chemokines including MIP-1-α, MIP-1-β, and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. CD195 is involved in the chemotaxis of leucocytes to inflammation sites and plays an important role in the recruitment of macrophages, T cells, and monocytes in inflammation. Additionally, CCR5 may have an indirect effect on cancer progression by controlling the antitumor immune response, since it has been demonstrated that its expression could promote tumor growth and contribute to tumor metastasis.
Additional information: Clone REA354 displays negligible binding to Fc receptors.

Alternative names

CCR5, AM4-7, CD195, CMKBR5

Technical specifications

  • Antigen: CD195 (CCR5)
  • Clone: REA354
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CCR5, AM4-7, CD195, CMKBR5
  • Entrez Gene ID: 12774
  • Molecular mass of antigen [kDa]: 41
  • Distribution of antigen: thymocytes, macrophages, dendritic cells, microglia
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC-Vio770
  • Selected references

    1. Doranz, B. J. et al. (1997) Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1. J. Virol. 71(9): 6305-6314
    2. Barashi, N. et al. (2013) Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology 58(3): 1021-1030
    3. Meyer, A. et al. (1996) Cloning and characterization of a novel murine macrophage inflammatory protein-1 alpha receptor. J. Biol. Chem. 271(24): 14445-14451
Product options: 2
130-120-168

CD195 (CCR5)-APC-Vio770, mouse

30 µg in 200 µL (1)
-
130-120-084

CD195 (CCR5)-APC-Vio770, mouse

150 µg in 1 mL (1)
-