CD193 (CCR3) antibodies, human

CD193 (CCR3) antibodies, human

Clone: REA574 | Dilution: 1:11
Clone REA547 recognizes the human CD193 antigen, a seven-transmembrane domain G protein–coupled receptor, also known as CCR3. CD193 binds a variety of chemokines, including eotaxin (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26), RANTES (CCL5), MCP-4 (CCL13), leukotactin (CCL15), and MEC (CCL28). CD193 is expressed by eosinophils, basophils, mast cells, platelets, CD34
+
hematopoietic progenitor cells, and keratinocytes, as well as by some T cell subsets, in particular Tʜ2 cells. CD193 regulates cell migration and activation and is a co-receptor for HIV.
Additional information: Clone REA547 displays negligible binding to Fc receptors.

Alternative Names

CCR3, CC-CKR-3, CKR3, CMKBR3

Technical specifications

  • Antigen: CD193 (CCR3)
  • Clone: REA574
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CCR3, CC-CKR-3, CKR3, CMKBR3
  • Entrez Gene ID: 1232
  • Molecular mass of antigen [kDa]: 41
  • Distribution of antigen: eosinophils, basophils, mast cells, platelets, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, VioBlue, APC-Vio770, Biotin

REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the other known clones. 

Other clonesOverlap in epitope recognition with REA574
5E8.4++
  • Selected References

    1. Combadiere, C. et al. (1995) Cloning and functional expression of a human eosinophil CC chemokine receptor. J. Biol. Chem. 270(28): 16491-16494
    2. Ponath, P. D. et al. (1996) Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J. Exp. Med. 183(6): 2437-2448
    3. Xiao, L. et al. (1999) Partial resistance to infection by R5X4 primary HIV type 1 isolates in an exposed-uninfected individual homozygous for CCR5 32-base pair deletion. AIDS Res Hum Retroviruses 15(13): 1201-1208

Related products

1 products available
Product options: 8

Product information

Size
Order no.
Price

CD193 (CCR3)-APC, human

  • REA574
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-920
-

CD193 (CCR3)-APC, human

  • REA574
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-890
-

CD193 (CCR3)-VioBlue, human

  • REA574
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-917
-

CD193 (CCR3)-VioBlue, human

  • REA574
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-887
-

CD193 (CCR3)-APC-Vio770, human

  • REA574
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-921
-

CD193 (CCR3)-APC-Vio770, human

  • REA574
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-891
-

CD193 (CCR3)-Biotin, human

  • REA574
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-916
-

CD193 (CCR3)-Biotin, human

  • REA574
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-886
-