CD193 (CCR3) antibodies, human

CD193 (CCR3) antibodies, human

Clone: REA574 | Dilution: 1:11
Clone REA547 recognizes the human CD193 antigen, a seven-transmembrane domain G protein–coupled receptor, also known as CCR3. CD193 binds a variety of chemokines, including eotaxin (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26), RANTES (CCL5), MCP-4 (CCL13), leukotactin (CCL15), and MEC (CCL28). CD193 is expressed by eosinophils, basophils, mast cells, platelets, CD34
+
hematopoietic progenitor cells, and keratinocytes, as well as by some T cell subsets, in particular Tʜ2 cells. CD193 regulates cell migration and activation and is a co-receptor for HIV.
Additional information: Clone REA547 displays negligible binding to Fc receptors.

Alternative names

CCR3, CC-CKR-3, CKR3, CMKBR3

Technical specifications

  • Antigen: CD193 (CCR3)
  • Clone: REA574
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CCR3, CC-CKR-3, CKR3, CMKBR3
  • Entrez Gene ID: 1232
  • Molecular mass of antigen [kDa]: 41
  • Distribution of antigen: eosinophils, basophils, mast cells, platelets, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, VioBlue, APC-Vio770, Biotin
  • Selected references

    1. Combadiere, C. et al. (1995) Cloning and functional expression of a human eosinophil CC chemokine receptor. J. Biol. Chem. 270(28): 16491-16494
    2. Ponath, P. D. et al. (1996) Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J. Exp. Med. 183(6): 2437-2448
    3. Xiao, L. et al. (1999) Partial resistance to infection by R5X4 primary HIV type 1 isolates in an exposed-uninfected individual homozygous for CCR5 32-base pair deletion. AIDS Res Hum Retroviruses 15(13): 1201-1208
Product options: 8
for 30
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for 100
tests
(1)
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for 30
tests
(1)
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for 100
tests
(1)
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for 30
tests
(1)
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for 100
tests
(1)
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for 30
tests
(1)
-
for 100
tests
(1)
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