CD183 (CXCR3) antibodies, human

CD183 (CXCR3) antibodies, human

Clone: REA232 | Dilution: 1:50
Clone REA232 recognizes CD183, a 38 kDa G protein–coupled chemokine receptor. CD183 harbors seven-transmembrane α-helices, an extracellular N-terminal domain containing three loops involved in the chemokine ligand binding, an intracellular C-terminal domain involved in signal transduction. CD183 binds CXCL9, CXCL10, and CXCL11 as ligands. CD183-ligand interactions play role in diverse cellular functions such as chemotactic migration, cell proliferation, and death. Expression of CD183 is found on T cells, human airway epithelial cells, NK cells, plasmacytoid dendritic cells, mast cells, alveolar macrophages, and eosinophils.
Additional information: Clone REA232 displays negligible binding to Fc receptors.

Alternative Names

CXCR3, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR
REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the different hybridoma clones. 
Other clonesOverlap in epitope recognition with REA232

Technical specifications

  • Antigen: CD183 (CXCR3)
  • Clone: REA232
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CXCR3, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR
  • Distribution of antigen: T cells, epithelial cells, NK cells, mast cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC
Product options: -

Product information

Order no.

Related products

4 products available