CD181 (CXCR1) antibodies, human

CD181 (CXCR1) antibodies, human

Clone: 8F1 | Dilution: 1:11
Clone 8F1 recognizes the human CD181 antigen, a multi-pass membrane protein also known as C-X-C chemokine receptor type 1 (CXCR1) or IL-8 receptor A (IL-8RA). CD181 is expressed as homodimer or heterodimer with CD182 (CXCR2) and found on granulocytes, NK cells, a subset of T lymphocytes, mast cells, monocytes, endothelial cells, megakarocytes, and oligodendrocytes. It is one of two high-affinity receptors for IL-8, a major mediator of immune and inflammatory responses implicated in many disorders, including tumor growth. IL-8, released in response to inflammatory stimuli, binds to the extracellular part of CD181. The ligand-activated intracellular signaling pathways results in neutrophil migration to the site of inflammation.

Alternative Names

CXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA

Technical specifications

  • Antigen: CD181 (CXCR1)
  • Clone: 8F1
  • Isotype: mouse IgG2bκ
  • Isotype control: Mouse IgG2b – isotype control antibodies
  • Alternative names of antigen: CXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
  • Entrez Gene ID: 3577
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: granulocytes, NK cells, lymphocytes, mast cells, monocytes, endothelial cells, megakaryocytes, oligodendrocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio770, APC-Vio770, PerCP-Vio700
  • Selected References

    1. Cummings, C. J. et al. (1999) Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis. J. Immunol. 162(4): 2341-2346
    2. Angelis, A. A. et al. (2012) Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature 491(7426): 779-783
    3. Holmes, W. E. et al. (1991) Structure and functional expression of a human interleukin-8 receptor. Science 253(5025): 1278
Product options: 16
130-105-392

CD181 (CXCR1)-FITC, human

for 30
tests
(1)
-
130-105-351

CD181 (CXCR1)-FITC, human

for 100
tests
(1)
-
130-105-393

CD181 (CXCR1)-PE, human

for 30
tests
(1)
-
130-105-352

CD181 (CXCR1)-PE, human

for 100
tests
(1)
-
130-105-394

CD181 (CXCR1)-APC, human

for 30
tests
(1)
-
130-105-353

CD181 (CXCR1)-APC, human

for 100
tests
(1)
-
130-105-391

CD181 (CXCR1)-VioBlue, human

for 30
tests
(1)
-
130-105-350

CD181 (CXCR1)-VioBlue, human

for 100
tests
(1)
-
130-105-390

CD181 (CXCR1)-VioGreen, human

for 30
tests
(1)
-
130-105-349

CD181 (CXCR1)-VioGreen, human

for 100
tests
(1)
-
130-105-395

CD181 (CXCR1)-PE-Vio770, human

for 30
tests
(1)
-
130-105-354

CD181 (CXCR1)-PE-Vio770, human

for 100
tests
(1)
-
130-105-396

CD181 (CXCR1)-APC-Vio770, human

for 30
tests
(1)
-
130-105-355

CD181 (CXCR1)-APC-Vio770, human

for 100
tests
(1)
-
130-105-397

CD181 (CXCR1)-PerCP-Vio700, human

for 30
tests
(1)
-
130-105-356

CD181 (CXCR1)-PerCP-Vio700, human

for 100
tests
(1)
-