CD18 antibodies, mouse

CD18 antibodies, mouse

Clone: M18/2 | Dilution: 1:10
Clone M18/2 recognizes the CD18 antigen, a 95 kDa glycoprotein also known as integrin beta-2 (ITGB2). CD18 associates non-covalently with CD11a, CD11b, and CD11c to form LFA-1, Mac-1, and gp150/95, respectively and plays an important role in leukocytes adhesion. It is expressed on all leukocytes with NK and T cells showing higher density of surface expression. The CD18 integrin complexes bind CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), iC3b, and fibrinogen. Heterodimers of CD18 with α subunits show different expression patterns on different leucocytes. Mice leucocytes lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.

Alternative Names

Integrin beta-2 (ITGB2), 2E6, LAD, Lfa1, MF17, LCAMB, TNFR2-RP

Technical specifications

  • Antigen: CD18
  • Clone: M18/2
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: Integrin beta-2 (ITGB2), 2E6, LAD, Lfa1, MF17, LCAMB, TNFR2-RP
  • Entrez Gene ID: 16414
  • Molecular mass of antigen [kDa]: 86,7
  • Distribution of antigen: T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
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