CD178 antibodies, human

CD178 antibodies, human

Clone: REA1056 | Dilution: 1:50
Clone REA1056 recognizes the CD178 antigen, a type II transmembrane glycoprotein also known as Fas ligand or CD95L. It is expressed on activated lymphocytes, e.g., T cells, NK cells, monocytes, or granulocytes, as well as at immune-privileged sites, e.g., cornea or testis. CD178 can trigger apoptosis through trimerization of the Fas receptor CD95. Thereby, CD178 and CD95 play a key role in the regulation of the immune system. Cleavage of membrane-bound CD178 from the cell surface via matrix metalloproteinases (such as MMP-7) generates soluble CD178 molecules.
Additional information: Clone REA1056 displays negligible binding to Fc receptors.

Alternative Names

FASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6

Technical specifications

  • Antigen: CD178
  • Clone: REA1056
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6
  • Entrez Gene ID: 356
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: dendritic cells, endothelial cells, epithelial cells, granulocytes, lymphocytes, monocytes, NK cells, T cells, neutrophils, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, VioBright 515
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