CD177 antibodies, human

CD177 antibodies, human

Clone: REA258 | Dilution: 1:11
Clone REA258 recognizes CD177, which is also known as neutrophil specific antigen 1. CD177, a member of the µPAR family, is a 58–64 kDa glycosylphosphatidylinositol-anchored glycoprotein expressed exclusively by subset of neutrophils, neutrophilic metamyelocytes, and myelocytes and is suggested to play a role in neutrophil mediated immune reponse as evident by its up-regulation on neutrophils in a number of inflammatory settings such as bacterial infection. Furthermore, CD177 can directly bind to PECAM-1 allowing neutrophil-endothelial cell interactions and thus contributing to neutrophil transmigration. Overexpression of CD177 is also seen in patients with polycythemia vera, making it a useful diagnostic marker.
Additional information: Clone REA258 displays negligible binding to Fc receptors.

Alternative Names

HNA-2a, NB1, NB1 GP, PRV-1, PRV1

Technical specifications

  • Antigen: CD177
  • Clone: REA258
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HNA-2a, NB1, NB1 GP, PRV-1, PRV1
  • Entrez Gene ID: 57126
  • Molecular mass of antigen [kDa]: 41
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
  • Distribution of antigen: neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
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