CD172b (SIRPβ) antibodies, human

CD172b (SIRPβ) antibodies, human

Clone: B4B6 | Dilution: 1:11
Clone B4B6 recognizes the human CD172b antigen, a single-pass type I membrane protein also known as signal-regulatory protein beta (SIRPβ). SIRPs are a family of transmembrane receptor-like signaling proteins that are abundantly expressed in hematopoietic cells, including granulocytes, monocytes, dendritic cells, and lymphocytes. In addition, SIRPs are expressed in neuronal cells and certain types of cancer cells. SIRPs can be divided into two subfamilies, CD172a and CD172b, based on the putative structures of their C-terminal intracellular domains which distinguish them as either activating (CD172b) or inhibitory (CD172a) isoforms. CD172b is expressed on peripheral blood monocytes, dendritic cells, and granulocytes.

Alternative Names

SIRPB1, SIRP-BETA-1

Technical specifications

  • Antigen: CD172b (SIRPβ)
  • Clone: B4B6
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: SIRPB1, SIRP-BETA-1
  • Entrez Gene ID: 10326
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: granulocytes, monocytes, dendritic cells, lymphocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected References

    1. Dietrich, J. et al. (2000) Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. J. Immunol. 164(1): 9-12
    2. Kharitonenkov, A. et al. (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386(6621): 181-186
    3. Liu, Y. et al. (2005) SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. J. Biol. Chem. 280(43): 36132-36140
Product options: 12

Product information

Size
Order no.
Price

CD172b (SIRPβ)-VioBright FITC, human

  • B4B6
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-313
-

CD172b (SIRPβ)-VioBright FITC, human

  • B4B6
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-271
-

CD172b (SIRPβ)-PE, human

  • B4B6
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-310
-

CD172b (SIRPβ)-PE, human

  • B4B6
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-268
-

CD172b (SIRPβ)-APC, human

  • B4B6
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-484
-

CD172b (SIRPβ)-APC, human

  • B4B6
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-441
-

CD172b (SIRPβ)-PE-Vio770, human

  • B4B6
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-311
-

CD172b (SIRPβ)-PE-Vio770, human

  • B4B6
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-269
-

CD172b (SIRPβ)-APC-Vio770, human

  • B4B6
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-312
-

CD172b (SIRPβ)-APC-Vio770, human

  • B4B6
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-270
-

CD172b (SIRPβ)-Biotin, human

  • B4B6
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-309
-

CD172b (SIRPβ)-Biotin, human

  • B4B6
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-267
-